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Bruk av antidepressive midler og antipsykotika er ikke uvanlig ved akutte korsryggssmerter, til tross for det ikke finnes dokumentert effekt av disse på smerter eller sykdomsforløp.Noen ganger hovner skiven opp og forårsaker betydelig irritasjon på nerveroten som har sitt utspring i ryggmargen. Dette kan da gi isjias.Akutte smerter lindres godt
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